I have been seeing a plague hitting the AutoCAD world. A plague of bad Profiles. How in the world does a Profile go bad? I am scratching my head on that one. The symptoms, obviously things are not working right. VBA routines are not loading or worse yet, they load but then don't work. Same with the AcadDoc.LSP not loading at all. Yes, the paths are there in the Support Search path, but they just don't load. I can type in at the command line, (findfile "acaddoc.lsp") and it returns right where it should be. I can load it manually, but it won't work automatically. The out-of-box <<Unnamed Profile>> can't be used to rebuild either. Believe me, I tried it. Everything looks fine, but something is amiss somewhere.
Easiest thing to do?
The easiest fix is run Reset Settings to Default and don't save any custom settings. Start over on those. The Reset replaces the <<Unnamed Profile>>, which I recommend then to use Add to List... and add back in the custom folders to the newly created Profile. Everything seems happy after that.